GHRH Analog Research

Sermorelin

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99.661% · COA Verified · Lot 86168-78-7 · Freedom Diagnostics

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Research Overview

Sermorelin is a synthetic analog of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH 1–29). As the minimal biologically active fragment of GHRH, it is used as a research standard for GHRH receptor pharmacology and as a diagnostic tool in GH deficiency models.

Mechanism of Action

Sermorelin binds to GHRH receptors on pituitary somatotrophs, activating adenylate cyclase and triggering GH release via the cAMP/PKA pathway. Its short half-life (due to DPP-IV cleavage at the N-terminus) produces physiological pulsatile GH release that closely mimics endogenous GHRH signaling. It serves as the reference compound for GHRH analog pharmacology.

Experimental Applications

Research includes GH axis diagnostics, GHRH receptor pharmacology, pituitary somatotroph biology, GH deficiency models, comparison against modified GHRH analogs with extended half-lives, physiological GH pulse research, and pediatric growth research models.

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How Does Sermorelin Compare?

Growth Hormone Peptides

Property	Sermorelin	Ipamorelin	CJC-1295 DAC	Tesamorelin
Type	GHRH(1-29) Analog	GH Secretagogue / GHSR Agonist	Long-Acting GHRH Analog	GHRH Analog
Molecular Weight	3,357.88 g/mol	711.86 g/mol	3,647.28 g/mol	5,135.81 g/mol
Amino Acids	29	5	30	44
CAS Number	86168-78-7	170851-70-4	863288-34-0	218949-48-5
Formula	C₁₄₉H₂₄₆N₄₄O₄₂S	C₃₈H₄₉N₉O₅	C₁₅₂H₂₅₂N₄₄O₄₂	C₂₂₁H₃₆₆N₆₈O₇₂S
	CURRENT	View Product →	View Product →	View Product →

Research Use Only. All products sold exclusively for in vitro and qualified laboratory research. Not FDA-approved and not for human or animal consumption.