GHRH Analog Research
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Ipamorelin is a selective pentapeptide growth hormone secretagogue and ghrelin receptor (GHSR-1a) agonist. It is notable for its clean GH-releasing profile — producing robust GH pulses without significant cortisol, prolactin, or ACTH elevation — making it a precise tool for GH axis research.
Ipamorelin binds selectively to the GHSR-1a receptor on somatotroph cells, triggering intracellular calcium release and GH secretion. Unlike GHRH analogs, it does not require endogenous GHRH for activity and functions independently of the somatostatin tone. Its selectivity for GH release with minimal off-target hormone stimulation makes it valuable for research requiring clean GH elevation.
Research includes GHSR pharmacology, selective GH pulse studies, muscle anabolism models, bone density research, fat metabolism, aging and GH axis restoration, sleep architecture (GH is released during slow-wave sleep), and comparison with ghrelin mimetics and GHRH analogs.
Growth Hormone Peptides
| Property | Ipamorelin | CJC-1295 DAC | Sermorelin | Tesamorelin |
|---|---|---|---|---|
| Type | GH Secretagogue / GHSR Agonist | Long-Acting GHRH Analog | GHRH(1-29) Analog | GHRH Analog |
| Molecular Weight | 711.86 g/mol | 3,647.28 g/mol | 3,357.88 g/mol | 5,135.81 g/mol |
| Amino Acids | 5 | 30 | 29 | 44 |
| CAS Number | 170851-70-4 | 863288-34-0 | 86168-78-7 | 218949-48-5 |
| Formula | C₃₈H₄₉N₉O₅ | C₁₅₂H₂₅₂N₄₄O₄₂ | C₁₄₉H₂₄₆N₄₄O₄₂S | C₂₂₁H₃₆₆N₆₈O₇₂S |
| CURRENT | View Product → | View Product → | View Product → |
Research Use Only. All products sold exclusively for in vitro and qualified laboratory research. Not FDA-approved and not for human or animal consumption.
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