Melanocortin Receptor Research

PT-141

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99.482% · COA Verified · Lot 189691-06-3 · Freedom Diagnostics

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Research Overview

PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist derived from Melanotan II through removal of the C-terminal amide. It acts centrally via MC4R in the hypothalamus to activate sexual arousal pathways without the cardiovascular effects of peripheral vasodilators, making it a unique CNS-targeted research compound.

Mechanism of Action

PT-141 activates MC3R and MC4R in the central nervous system, particularly in the hypothalamus and limbic system. MC4R agonism in dopaminergic circuits drives pro-sexual signaling and arousal. Unlike PDE5 inhibitors, PT-141 works through a central neuromodulatory mechanism independent of vascular tone, providing a neurochemically distinct approach to sexual function research.

Experimental Applications

Research includes melanocortin receptor pharmacology, sexual arousal CNS pathways, hypothalamic circuit mapping, appetite regulation via MC4R, pain sensitization studies, skin pigmentation research via MC1R, and neuropsychiatric model development.

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How Does PT-141 Compare?

Melanocortin Research

Property	PT-141	Melanotan II	Melanotan 1	AOD-9604
Type	Melanocortin Receptor Agonist	Pan-Melanocortin Receptor Agonist	α-MSH Analog (Linear)	Modified hGH Fragment (176–191)
Molecular Weight	1,025.20 g/mol	1,024.18 g/mol	1,646.87 g/mol	1,815.08 g/mol
Amino Acids	7	7	13	16
CAS Number	189691-06-3	121062-08-6	75921-69-6	221231-10-3
Formula	C₅₀H₆₈N₁₄O₁₀	C₅₀H₆₉N₁₅O₉	C₇₈H₁₁₁N₂₁O₁₉	C₇₈H₁₂₃N₂₃O₂₃S₂
	CURRENT	View Product →	View Product →	View Product →

Research Use Only. All products sold exclusively for in vitro and qualified laboratory research. Not FDA-approved and not for human or animal consumption.