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MOTS-c

GLP Receptor Agonist Research

MOTS-c

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98.913% · COA Verified · Lot 1627580-64-6 · Freedom Diagnostics
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Research Overview

MOTS-c is a 16-amino acid peptide encoded in the mitochondrial 12S rRNA gene, representing a new class of mitochondrial-derived peptides (MDPs). It is a potent metabolic regulator that translocates to the nucleus under stress conditions and modulates gene expression related to metabolic homeostasis and aging.

Mechanism of Action

MOTS-c activates AMPK (AMP-activated protein kinase) signaling to enhance glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. Under metabolic stress it translocates to the nucleus where it functions as a transcription regulator, modulating the folate cycle and reducing reactive oxygen species. It also influences the one-carbon metabolic pathway and shows anti-inflammatory and anti-aging properties in aging models.

Experimental Applications

Research includes mitochondrial biology and biogenesis, AMPK signaling, metabolic disease models, aging and longevity research, exercise physiology, skeletal muscle glucose metabolism, insulin sensitivity studies, oxidative stress and ROS biology, and mitochondrial-nuclear communication.

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How Does MOTS-c Compare?

Mitochondrial & Anti-Aging Peptides

PropertyMOTS-cTesamorelinIGF-1 LR3Thymosin Alpha-1
TypeMitochondrial PeptideGHRH AnalogIGF-1 Long Arg3 AnalogThymic Peptide / Immune Modulator
Molecular Weight2,174.38 g/mol5,135.81 g/mol9,111.03 g/mol3,108.32 g/mol
Amino Acids16448328
CAS Number1627580-64-6218949-48-5946870-92-462304-98-7
FormulaC₈₉H₁₄₆N₂₆O₂₆SC₂₂₁H₃₆₆N₆₈O₇₂SC₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉C₁₂₉H₂₁₅N₃₃O₅₅
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Research Use Only. All products sold exclusively for in vitro and qualified laboratory research. Not FDA-approved and not for human or animal consumption.

$75.00
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