Neuropeptide Research

Kisspeptin

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98.994% · COA Verified · Lot 359349-93-2 · Freedom Diagnostics

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Research Overview

Kisspeptin (specifically the 10-amino acid C-terminal fragment Kisspeptin-10) is an endogenous neuropeptide encoded by the KISS1 gene. It is the principal upstream activator of the hypothalamic-pituitary-gonadal (HPG) axis, making it a critical research compound for reproductive endocrinology and hormone regulation.

Mechanism of Action

Kisspeptin-10 binds to KISS1R (GPR54) on GnRH neurons in the hypothalamic arcuate and anteroventral periventricular nuclei, triggering pulsatile GnRH release. This drives downstream LH and FSH secretion from the anterior pituitary, stimulating gonadal steroidogenesis. The peptide also plays roles in tumor suppression (Kisspeptin was originally identified as a metastasis suppressor) and modulates sexual arousal-related neural circuits.

Experimental Applications

Research includes HPG axis regulation, GnRH pulsatility studies, reproductive endocrinology, fertility research, hypogonadism models, KISS1R pharmacology, pubertal timing research, cancer biology (metastasis suppression), and neuroendocrine circuit mapping.

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How Does Kisspeptin Compare?

Neuropeptide Research

Property	Kisspeptin	PT-141	Melanotan II	Selank
Type	Neuropeptide / GnRH Stimulator	Melanocortin Receptor Agonist	Pan-Melanocortin Receptor Agonist	Anxiolytic Heptapeptide
Molecular Weight	1,302.46 g/mol	1,025.20 g/mol	1,024.18 g/mol	751.84 g/mol
Amino Acids	10	7	7	7
CAS Number	359366-34-5	189691-06-3	121062-08-6	129954-34-3
Formula	C₆₃H₈₃N₁₅O₁₄	C₅₀H₆₈N₁₄O₁₀	C₅₀H₆₉N₁₅O₉	C₃₃H₅₇N₁₁O₉
	CURRENT	View Product →	View Product →	View Product →

Research Use Only. All products sold exclusively for in vitro and qualified laboratory research. Not FDA-approved and not for human or animal consumption.