GLP Receptor Agonist Research
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GLP-3RT is a 39-amino acid acylated peptide designed as a triple agonist at GIP, GLP-1, and glucagon receptors simultaneously. The triple-incretin mechanism represents the next generation of metabolic peptide research, with glucagon receptor activity believed to drive enhanced energy expenditure and hepatic fat reduction.
GLP-3RT engages all three incretin-related receptors: GLP-1R drives insulin secretion and slows gastric emptying; GIPR provides complementary insulin and adipose effects; GCGR activation stimulates hepatic glycogenolysis, enhances energy expenditure in brown adipose tissue, and may drive superior fat loss relative to dual agonists. The combination produces pleiotropic metabolic effects studied for body composition and metabolic disease.
Research includes triple receptor pharmacology dose-response studies, comparative fat mass reduction vs. dual agonists, hepatic steatosis and NASH models, brown adipose thermogenesis, energy expenditure profiling, CNS weight regulation, and novel obesity intervention research.
GLP-1 & Metabolic Peptides
| Property | GLP-3RT | GLP-1SG | GLP-2TZ | AOD-9604 |
|---|---|---|---|---|
| Type | Triple GIP/GLP-1/Glucagon Agonist | GLP-1 Receptor Agonist | Dual GIP/GLP-1 Receptor Agonist | Modified hGH Fragment (176–191) |
| Molecular Weight | 4,731.28 g/mol | 4,113.58 g/mol | 4,813.45 g/mol | 1,815.08 g/mol |
| Amino Acids | 39 | 31 | 39 | 16 |
| CAS Number | 2381089-83-2 | 910463-68-2 | 2023788-19-2 | 221231-10-3 |
| Formula | C₂₃₁H₃₄₂N₄₈O₆₈ | C₁₈₇H₂₉₁N₄₅O₅₉ | C₂₂₅H₃₄₈N₄₈O₆₈ | C₇₈H₁₂₃N₂₃O₂₃S₂ |
| CURRENT | View Product → | View Product → | View Product → |
Research Use Only. All products sold exclusively for in vitro and qualified laboratory research. Not FDA-approved and not for human or animal consumption.
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